TCM’s Potential in Preventing and Treating Cognitive Decline
Senior Health

TCM’s Potential in Preventing and Treating Cognitive Decline

Regina Robles, LAc, DAOM
WHAT YOU NEED TO KNOW
  • Cognitive decline is a complex, multifactorial condition with roots in a variety of medical, lifestyle and environmental factors.
  • Emerging studies suggest acupuncture may promote cerebral blood flow, modulate neurotransmitter levels and reduce neuroinflammation — all key mechanisms implicated in the progression of cognitive decline.
  • TCM herbal formulations offer additional support for cognitive function, leveraging neuroprotective, anti-inflammatory and antioxidant mechanisms.

Cognitive decline affects a growing number of individuals each year. In the United States alone, approximately one in nine adults (11.1%) report experiencing subjective cognitive decline (SCD) – a self-perceived worsening or more frequent confusion or memory loss.1 A comparable percentage will go on to develop Alzheimer’s disease or other forms of dementia.2

As researchers and clinicians seek integrative solutions outside of conventional pharmacological approaches, traditional Chinese medicine (TCM) emerges as a promising, multimodal strategy in the prevention and treatment of cognitive decline. Let’s explore the potential role of acupuncture and Chinese herbal medicine in addressing cognitive deterioration and supporting brain health.

Understanding the Etiology of Cognitive Decline

Cognitive decline is a complex, multifactorial condition with roots in a variety of medical, lifestyle and environmental factors. Neurodegenerative diseases such as Alzheimer’s, vascular dementia, Parkinson’s, and Huntington’s disease are known contributors. Other significant influences include aging, physical inactivity, poor nutrition, smoking, chronic stress, and metabolic syndromes.

Additional risk factors include genetic predisposition, traumatic brain injuries, infections, pharmaceutical side effects, and environmental toxins. A comprehensive understanding of these contributing elements is crucial to formulating holistic treatment strategies — making TCM particularly well-suited due to its emphasis on individualized diagnosis and treatment.

Acupuncture and Cognitive Function: A Review of Current Evidence

Acupuncture continues to gain attention for its neuroregulatory effects and potential role in cognitive health. Emerging studies suggest acupuncture may promote cerebral blood flow, modulate neurotransmitter levels and reduce neuroinflammation — all key mechanisms implicated in the progression of cognitive decline.3

Clinical and preclinical findings are promising. One human study demonstrated that elderly patients with subjective cognitive decline experienced increases in hippocampal volume and improved functional brain connectivity following acupuncture treatment.4 Another study reported cognitive improvements in older adults with mild cognitive impairment (MCI) after consistent acupuncture sessions.5

Animal models provide further insight. In one study, rats with induced cognitive impairment — caused by chronic stress, social isolation and chemical exposure — showed significant gains in learning and memory after receiving acupuncture therapy.6

Although human trials remain limited, the cumulative evidence supports acupuncture as a safe, non-invasive adjunct therapy with potential for both prevention and treatment of cognitive dysfunction.

Chinese Herbal Medicine and Neuroprotection

TCM herbal formulations offer additional support for cognitive function, leveraging neuroprotective, anti-inflammatory and antioxidant mechanisms. Several botanicals commonly used in Chinese medicine have demonstrated potential benefits in maintaining brain health and slowing cognitive decline.

Panax ginseng (ren shen): Widely studied for its adaptogenic properties, ginseng has been shown to improve memory and cognitive performance in both healthy individuals and those with cognitive impairments.7

Salvia miltiorrhiza (dan shen): Traditionally used to promote cardiovascular and cerebrovascular health, dan shen contains active compounds such as salvianolic acid B, which may reduce oxidative stress and inflammation in the brain. While studies in mice show encouraging results, limited bioavailability in humans has prompted the development of more effective delivery methods, including nanopharmaceutical formulations.8

Curcumin (from turmeric/jiang huang): Known for its potent anti-inflammatory and antioxidant properties, curcumin has demonstrated improvements in working memory. However, gastrointestinal side effects remain a challenge, underscoring the need for further research into safer and more effective dosing strategies.8

Polygala tenuifolia (yuan zhi): Long used in TCM for cognitive and emotional disorders, yuan zhi has shown promise in experimental models of Alzheimer’s disease. Research in mice demonstrated improved memory, and spatial orientation, and reductions in beta-amyloid plaques and tau protein deposits in the hippocampus.9

Collectively, these herbs represent a compelling case for the integration of TCM herbs in cognitive care. Nonetheless, standardized clinical trials are essential to confirm safety, efficacy and dosage guidelines appropriate for broader medical use.

Practical Takeaway

 As rates of cognitive impairment rise, there is an increasing need for safe, effective and accessible interventions. TCM – through its holistic lens and centuries of clinical application – offers promising avenues for both the prevention and treatment of cognitive decline.

Acupuncture and herbal medicine, in particular, may serve as valuable adjuncts to conventional care by promoting neuroprotection, reducing inflammation,and supporting healthy brain function. While further research is necessary to fully substantiate their role, the existing evidence – combined with clinical experience – suggests integration of TCM into mainstream cognitive health strategies is not only warranted, but essential.

References

  1. Subjective Cognitive Decline - A Public Health Issue. Centers for Disease Control and Prevention.
  2. Alzheimer’s Disease Facts and Figures. Alzheimer’s Association: www.alz.org/alzheimers-dementia/facts-figures.
  3. Sartori AC, Vance DE, Slater LZ, Crowe M. The impact of inflammation on cognitive function in older adults. J Neurosci Nurs, 2012;44(4):206-217.
  4. Wang X, et al. Cognitive and hippocampal changes in older adults with subjective cognitive decline after acupuncture intervention. Am J Geriatr Psychiatry, 2024 Aug;32(8):1014-102.
  5. Li W, Wang Q, Du S, et al. Acupuncture for mild cognitive impairment in elderly people: systematic review and meta-analyses. Medicine, 2020;99(39):e22365.
  6. Leung MC, et al. Acupuncture improves cognitive function: a systematic review. Neural Regen Res, 2013;8(18):1673-1684.
  7. Lee R, et al. Emerging evidence that ginseng components improve cognition in subjective memory impairment, mild cognitive impairment, and early Alzheimer’s disease dementia. J Ginseng Res, 2024;48(3):245-252.
  8. Tsai I-C, et al. The effect of curcumin differs on individual cognitive domains: a systematic review and meta-analysis. Pharmaceuticals, 2021;14(12):1235.
  9. Wu Q, et al. Yuan-Zhi decoction in the treatment of Alzheimer’s disease: an integrated approach. Front Pharmacol, 2022;13:893244.
January 2026
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