SAMe stands for S-adenosyl-L-methionine, a chemical compound found in the human body and produced by the liver. Although the full extent of SAMe research has yet to be conducted, it is believed to play a role in more than 40 essential biochemical reactions, and is responsible for the manufacture of brain chemicals, antioxidants, joint tissue structures, and other vital components essential for life.
SAMe plays a vital role in the management of depression, as it can raise levels of dopamine, a neurotransmitter responsible for regulating a person's mood. While it does not work as well as some prescription antidepressants, it does appear to work faster - often within one week of the first dose. SAMe also has anti-inflammatory and palliative properties, and is often used to heal and strengthen joints. It is particularly useful for people with osteoarthritis, fibromyalgia, stiffness in the joints and swelling
Preliminary research suggests that SAMe can help treat a variety of liver conditions, ranging from cirrhosis to Gilbert's syndrome. One study published in 1999 found that people with cirrhosis due to alcohol had a 47 percent lower death or transplant rate when they took SAMe for two years compared to people taking a placebo.
Other uses for SAMe include treating migraine headaches, increasing sperm activity in infertile men, and reducing the symptoms of post-concussion syndrome.
Because SAMe is produced naturally by the liver, healthy people do not need to take SAMe supplements. However, some recommended levels have been established for individuals with particular conditions, including depression (1,600 mg per day); osteoarthritis (800-1,200 mg per day); fibromyalgia (800 mg per day); liver disorders (1,200 mg per day); and migraines (800 mg per day). Make sure to consult with a licensed health care provider before taking SAMe supplements.
SAMe is produced naturally by the body, and is related to methionine, an amino acid plentiful in many protein-rich foods. In the United States, SAMe supplements have been available since 1997. Some studies have used SAMe injections instead of pills or capsules.
Large doses of SAMe may cause gastrointestinal distress in some people. In addition, there is evidence that people with bipolar disorder who are treated with SAMe may switch from depression to a manic state. In addition, SAMe may interfere with the absorption of some tricylic antidepressants, such as Elavil or Norpramin. Patients on these medications should consult with a doctor before taking SAMe supplements. Folic acid and vitamin B12 are necessary for the synthesis of SAMe; patients with low levels of these nutrients may have low SAMe levels in the nervous system as a result. As always, make sure to consult with a licensed health care provider before taking SAMe or any other dietary supplement or herbal medicine.
References
Over my almost 30 years in clinical practice, I have used Chai Hu Long Gu Mu Li Tang extensively for a wide array of clinical presentations ranging from chronic headaches to anxiety, insomnia, and prescription drug withdrawal symptoms if these situations fit the appropriate patterns – all with extremely positive clinical outcomes.
There’s no doubt that many of your patients visit your practice because they are in pain. And there’s certainly no doubt that curcumin from turmeric (Curcuma longa) can be incredibly effective in stopping that pain, whether due to chronic conditions like arthritis or acute pain from intensive workouts. But your patients may also benefit from curcumin for other reasons.
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Low back pain is defined as pain the posterior superior iliac spine (PSIS), and it can be acute or chronic, localized or radiating. It is a common ailment for adults in the United States, with a lifetime prevalence as high as 65-80%. Whether or not an MRI is available to provide definitive knowledge of a structural issue, acupuncture can be an effective treatment for low back pain.
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