Chronic / Acute Conditions

Managing Autoimmune Diseases With TCM

Herbal Medicine and Acupoint Recommendations
Christine Chang, DAOM, LAc, Dipl. OM
WHAT YOU NEED TO KNOW
  • Autoimmune diseases are a diverse group of chronic conditions characterized by dysregulated immune responses, whereby the body mistakenly attacks its own tissues.
  • Conventional medical management has achieved significant progress through immunosuppressive and biologic therapies; however, these approaches are often associated with incomplete results, adverse effects and long-term safety concerns.
  • TCM offers a comprehensive framework for supporting individuals with autoimmune diseases by addressing systemic imbalance, inflammation and the dynamic nature of immune dysregulation.

Autoimmune diseases are a diverse group of chronic conditions characterized by dysregulated immune responses, whereby the body mistakenly attacks its own tissues. Disorders such as rheumatoid arthritis, systemic lupus, multiple sclerosis, inflammatory bowel syndrome, and autoimmune thyroid dysfunctions impose a substantial burden on patients and healthcare systems worldwide.

Conventional medical management has achieved significant progress through immunosuppressive and biologic therapies; however, these approaches are often associated with incomplete results, adverse effects and long-term safety concerns. Traditional Chinese medicine has attracted growing interest as a complementary approach to managing autoimmune diseases, offering a holistic and individualized model of care.

Foundations of TCM and Autoimmune Disease

Autoimmune diseases often arise from an imbalance in the body. For example, yin depletion can lead to the production of large amounts of autoantibodies, while excess yang can attack the internal organs, leading to deficiency heat rising. In this case, it’s not a sign of a weakened immunity, but rather an overactive immune system.

It is also believed that the invasion of the body by the six pathogenic factors can deplete yin fluids or prevent them from being distributed, leading to a deficiency of body fluids. When the internal organs and meridians are not properly nourished and the flow of qi is obstructed, pathological products such as blood stasis and phlegm accumulation will also aggravate the deficiency of yin fluids. For example, chronic inflammation may be interpreted as internal deficiency heat, and fatigue and weakness may indicate weakness of qi.

Treatment is guided by pattern differentiation rather than by disease labels alone. This, either alone or in conjunction with conventional treatment , can result in personalized and better outcomes.

Chinese Herbal Medicine’s Role in Autoimmune Disease

Chinese herbal medicine plays a prominent role in the management of autoimmune diseases. Each formula is tailored to the individual’s TCM pattern and adjusted as the condition evolves.

Herbal strategies may include nourishing methods to nourish yin and replenish qi, clearing-heat methods to reduce inflammation heat, and detoxifying and activating/moving methods to improve circulation and relieve pain.1

In autoimmune arthritis, for instance, the herbs that dispel wind and transfer phlegm are often used in tandem with those that nourish blood and support the liver and kidney functions.

Typical autoimmune support formulas include those in the Liu Wei Di Huang Wan series such as Ba Wei Di Huang Wan, Zhi Bai Di Huang Wan, Da Bu Yin Wan, Zuo Gui Wan, Ji Sheng Shen Qi Wan, and Mai Wei Di Huang Wan. Alternatively, a beneficial herbal formula may consist of:

  • Xuan shen: 30 g
  • Mai men dong: 15 g
  • Sheng di huang: 15 g
  • Sheng huang qi: 15 g
  • Dang gui: 15 g
  • Wang bu liu xing: 15 g
  • Bai hua she she cao: 30 g
  • Zao xiu: 15 g
  • Gan cao: 6 g

A study published in Medicina also found that using TCM herbal formulas for this same autoimmune condition dramatically reduced the prevalence of Sjögren’s syndrome, a common extra-articular feature among patients with arthritis.2 The following formulas may treat symptoms of various patterns of Sjögren’s syndrome:

  1. Yin deficiency internal heat: For liver & kidney deficiency, Qi Ju Ding Huang Wan with Yi Guan Jian (modify); for spleen & stomach yin deficiency, Yi Wei Tang with Yu Nu Jian (modify); for lung and stomach yin deficiency, Bai He Gu Jin Tang with Yi Wei Tang and Yu Nu Jian (modify).
  2. Qi & yin deficiency: Sheng Mai Yin with Ba Zhen Tang and Yi Guan Jian (modify).
  3. Qi deficiency with yang deficiency: Bu Zhong Yi Qi Tang, Li Zhong Tang, Shen Ling Bai Zhu San or Ba Wei Di Huang Wan (modify).
  4. Qi and blood stagnation: Xu Fu Zhu Yu Tang, Tao Hong Si Wu Tang (modify)

Contemporary research has identified bioactive compounds in several Chinese herbs with immunomodulatory and anti-inflammatory effects.3 These findings suggest herbal formulas may influence cytokine production, and regulate immune cell function and oxidative stress pathways.4

From a TCM perspective, diseases can be divided into four stages, each with effective TCM formulations:

  • 1st stage: Ying wei disharmony – Gui Zhi Tang, Chai Hu Gui Zhi Tang (modify)
  • 2nd stage: Qi stagnation with yin depleted – Si Ni San, Si Wu Tang (modify)
  • 3rd stage: Yin deficiency with fire excess – Long Dan Xie Gan Tang, Yi Guan Jian, Da Bu Yin Wan (modify).
  • Late stage: Yin depleted with blood stagnation – Da Ding Feng Zhu, Da Huang Zhe Cong Wan (modify).

Acupuncture and Immune Regulation

Acupuncture therapy is another widely utilized TCM modality in autoimmune disease care. Xia San Huang is the set of three separate points that are frequently used together. Some other useful acupuncture points include:

  • Ren 2 (Qugu), ST 29 (Gui Lai), Ren 4 (Guanyuan) to address vulvar atrophy or itching.
  • ST 2 (Sibai), YuYao (Ex), LI 4 (He Gu) to address dry eyes.
  • ST 4 (Di Cang), ST 6 (Jiache), ST 36 (Zusanli) to address dry mouth.

From a biomedical perspective, acupuncture therapy has been shown to affect neuroendocrine and immune function,5 including modulation of inflammatory mediators and autonomic nervous system activity. For example, to regulate kidney water and nourishing internal organs, use the Du Channel: DU 14 (Dazhui), DU 13 (Taodao), DU 12 (Shenzhu), DU 11 (Shendao), DU 10 (Lingtai), DU 9 (Zhiyang), DU 8 (Jinsuo), and DU 7 (Zhongshu) alongside KD 1 (Yongquan), and KD 3 (Taixi), once a week, totaling 15 treatments.

Although acupuncture therapy does not replace disease-modifying therapies, it may offer meaningful symptomatic relief and improve overall well-being when used as part of an integrative treatment plan.

Randomized, controlled studies support the use of acupuncture therapy as a treatment option for a wide variety of autoimmune conditions. These include rheumatoid arthritis, Crohn’s disease, multiple sclerosis, and others.6. Substantial research suggests this type of treatment triggers self-healing mechanisms within the body to restore homeostasis.7

Acupuncture therapy is also widely tolerated, resulting in minimal reported side-effects, making it a safe and effective treatment option, both independently or in conjunction with conventional medical care.

Integrative and Individualized Care

One of the defining strengths of TCM in autoimmune disease management is its emphasis on individualized and holistic long-term care. Autoimmune diseases often follow a relapsing–remitting pattern, and at-home care or self-acupressure can be easily adjusted over time in response to changes in symptoms and overall constitution.

Helpful acupressure points may include: LI 4 (Hegu), PC 7 (Daling), PC 6 (Neiguan), SJ 5 (Waiguan), ST 6 (Jiache), LI 5 (Yangxi), and KD 10 (Yingu). This flexible approach can complement conventional medicine by addressing residual symptoms, medication side effects and psychosocial factors throughout the natural cycle of autoimmune conditions.

Clinical Takeaway

TCM offers a comprehensive framework for supporting individuals with autoimmune diseases by addressing systemic imbalance, inflammation and the dynamic nature of immune dysregulation. Through individualized treatment strategies that may include acupuncture, herbal medicine, and lifestyle guidance, TCM can support symptom management and improve quality of life alongside conventional care.

References

  1. Zhang L, Cao Z, Yang Y, et al. Traditional Chinese medicine on treating active rheumatoid arthritis: a protocol for systematic review and meta-analysis. Medicine, 2020 Jun 12;99(24):e20642.
  2. Liao H-H, Livneh H, Lin M-C, et al. Relationship between Chinese herbal medicine use and risk of Sjögren’s syndrome in patients with rheumatoid arthritis: a retrospective, population-based, nested case-control study. Medicina, 2023;59(4):683.
  3. Pan M-H, Chiou Y-S, Tsai M-L, Ho C-T. Anti-inflammatory activity of traditional Chinese medicinal herbs, J Tradit Compl Med, 2011;1(1):8-24.
  4. Yang X, He T, Han S, et al. The role of traditional Chinese medicine in the regulation of oxidative stress in treating coronary heart disease. Oxid Med Cell Longev, 2019 Feb 24;2019:3231424.
  5. Cui J, Song W, Jin Y, et al. Research progress on the mechanism of the acupuncture regulating neuro-endocrine-immune network system. Vet Sci, 2021 Jul 30;8(8):149.
  6. Gamus D, Shoenfeld Y. Acupuncture therapy in autoimmune diseases: a narrative review. Autoimmun Rev, 2025 Jan 31;24(2):103709.
  7. Wang M, Liu W, Ge J, Liu S. The immunomodulatory mechanisms for acupuncture practice. Front Immunol, 2023;14:1147718.
October 2026